A number of clinical studies have been performed in order to ascertain the value of natural compounds in improving signs of aging, – Here are a few:
- Aloe: A 2009 study in women, published in the Annals of Dermatology, found that the daily ingestion of between 1.2 and 3.6 grams of aloe gel, taken daily for 90 days, significantly improved wrinkles and elasticity in photoaged skin in healthy female subjects over the age of 45.
- Pine Bark: A 2012 study in women, published in the journal Clinical Interventions in Aging, found that oral administration of 40 mg or 100 mg of French maritime pine bark (pycnogenol), daily for 12 weeks,, improved clinical symptoms in photoaged facial skin.
- Chocolate: A 2006 study in women, published in the Journal of Nutrition, found that long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced redness (erythema) and improves skin condition.
- Green Tea: A 2005 study in women, published in the journal Dermatologic Surgery, found that a combination of topical and oral green tea supplementation resulted in improvement in skin elasticity following exposure to ultraviolet light.
- Multi-Nutrient Mixtures: In 2004, a study published in the Journal of Dermatological Treatment found that a multi-nutrient mixture of vitamin C, vitamin E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and pycnogenol improved visible signs of aging in women 45-73 years of age after only 6 weeks of treatment.
- In 2005, a study published in the Journal of International Medical Research found that a multi-nutrient mixture of marine proteins, alpha- lipoic acid, pine bark extract, vitamins and minerals is safe and efficacious in the treatment of aging symptoms of the skin in women, after six months.
- Finally, a 2006 study, published in European Journal of Clinical Nutrition, found that multi-nutrient mixture of soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract improves signs of skin aging in post-menopausal women, after six months.